USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q99685 USC-OGP 2-DE database:  Q99685 Q99685 General information about the entry View entry in simple text format Entry name Q99685 Primary accession number Q99685 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Monoglyceride lipase {ECO:0000312|HGNC:HGNC:17038}; Short=MGL {ECO:0000312|HGNC:HGNC:17038}; EC=3.1.1.23 {ECO:0000269|PubMed:22969151}; AltName: Full=HU-K5 {ECO:0000303|PubMed:9495531}; AltName: Full=Lysophospholipase homolog; AltName: Full=Lysophospholipase-like; AltName: Full=Monoacylglycerol lipase {ECO:0000303|PubMed:20079333}; Short=MAGL {ECO:0000303|PubMed:20079333};. Gene name Name=MGLL {ECO:0000312|HGNC:HGNC:17038} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0984: pI=6.88; Mw=32104 Cross-references UniProtKB/Swiss-Prot Q99685; MGLL_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name MGLL_HUMAN Primary accession number Q99685 Secondary accession number(s) B3KRC2 B7Z9D1 Q6IBG9 Q96AA5 Sequence was last modified on  May 10, 2004 (version 2) Annotations were last modified on  February 15, 2017 (version 151) Name and origin of the protein Description RecName: Full=Monoglyceride lipase {ECO:0000312|HGNC:HGNC:17038}; Short=MGL {ECO:0000312|HGNC:HGNC:17038}; EC=3.1.1.23 {ECO:0000269|PubMed:22969151}; AltName: Full=HU-K5 {ECO:0000303|PubMed:9495531}; AltName: Full=Lysophospholipase homolog; AltName: Full=Lysophospholipase-like; AltName: Full=Monoacylglycerol lipase {ECO:0000303|PubMed:20079333}; Short=MAGL {ECO:0000303|PubMed:20079333}; Gene name Name=MGLL {ECO:0000312|HGNC:HGNC:17038} Encoded on Name=MGLL {ECO:0000312|HGNC:HGNC:17038 Keywords 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase; Lipid biosynthesis; Lipid degradation; Lipid metabolism; Membrane; Nitration; Phosphoprotein; Reference proteome; Serine esterase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U67963; AAB39616.1; ALT_INIT; mRNA EMBL AJ270950; CAC43316.1; -; mRNA EMBL AK091314; BAG52334.1; -; mRNA EMBL AK315529; BAG37910.1; ALT_INIT; mRNA EMBL AK304844; BAH14267.1; -; mRNA EMBL CR456835; CAG33116.1; ALT_INIT; mRNA EMBL AC023593; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC117480; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471052; EAW79330.1; ALT_INIT; Genomic_DNA EMBL CH471052; EAW79331.1; ALT_INIT; Genomic_DNA EMBL BC000551; AAH00551.1; ALT_INIT; mRNA EMBL BC006230; AAH06230.1; ALT_INIT; mRNA EMBL BX640777; CAE45873.1; -; mRNA CCDS CCDS43148.1; -. [Q99685-1]; . CCDS CCDS58852.1; -. [Q99685-2]; . RefSeq NP_001003794.1; NM_001003794.2. [Q99685-1]; . RefSeq NP_001243514.1; NM_001256585.1. [Q99685-2]; . RefSeq NP_009214.1; NM_007283.6; . UniGene Hs.277035; -; . PDB 3HJU; X-ray; 2.20 A; A/B=2-303 PDB 3JW8; X-ray; 2.10 A; A/B=1-303 PDB 3JWE; X-ray; 2.70 A; A/B=1-303 PDB 3PE6; X-ray; 1.35 A; A=1-303 PDB 4UUQ; X-ray; 2.36 A; A/B=1-303 PDBsum 3HJU; -; . PDBsum 3JW8; -; . PDBsum 3JWE; -; . PDBsum 3PE6; -; . PDBsum 4UUQ; -; . ProteinModelPortal Q99685; -; . SMR Q99685; -; . BioGrid 116471; 4; . IntAct Q99685; 3; . MINT MINT-1414843; -; . STRING 9606.ENSP00000265052; -; . BindingDB Q99685; -; . ChEMBL CHEMBL4191; -; . GuidetoPHARMACOLOGY 1399; -; . SwissLipids SLP:000000315; -; . ESTHER human-MGLL; Monoglyceridelipase_lysophospholip; . MEROPS S33.979; -; . iPTMnet Q99685; -; . PhosphoSitePlus Q99685; -; . BioMuta MGLL; -; . DMDM 47117287; -; . MaxQB Q99685; -; . PaxDb Q99685; -; . PeptideAtlas Q99685; -; . PRIDE Q99685; -; . DNASU 11343; -; . Ensembl ENST00000398104; ENSP00000381176; ENSG00000074416. [Q99685-1]; . Ensembl ENST00000434178; ENSP00000402798; ENSG00000074416. [Q99685-1]; . Ensembl ENST00000453507; ENSP00000404146; ENSG00000074416. [Q99685-2]; . GeneID 11343; -; . KEGG hsa:11343; -; . UCSC uc003ejw.4; human. [Q99685-1]; . CTD 11343; -; . DisGeNET 11343; -; . GeneCards MGLL; -; . HGNC HGNC:17038; MGLL; . HPA HPA011348; -; . HPA HPA011993; -; . HPA HPA011994; -; . MIM 609699; gene; . neXtProt NX_Q99685; -; . OpenTargets ENSG00000074416; -; . PharmGKB PA30789; -; . eggNOG KOG1455; Eukaryota; . eggNOG COG2267; LUCA; . GeneTree ENSGT00390000011364; -; . HOGENOM HOG000003227; -; . HOVERGEN HBG049220; -; . InParanoid Q99685; -; . KO K01054; -; . PhylomeDB Q99685; -; . TreeFam TF329184; -; . BRENDA 3.1.1.23; 2681; . Reactome R-HSA-1482883; Acyl chain remodeling of DAG and TAG; . Reactome R-HSA-163560; Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis; . Reactome R-HSA-426048; Arachidonate production from DAG; . UniPathway UPA00256; -; . ChiTaRS MGLL; human; . EvolutionaryTrace Q99685; -; . GenomeRNAi 11343; -; . PRO PR:Q99685; -; . Proteomes UP000005640; Chromosome 3; . Bgee ENSG00000074416; -; . CleanEx HS_MGLL; -; . ExpressionAtlas Q99685; baseline and differential; . Genevisible Q99685; HS; . GO GO:0005829; C:cytosol; ISS:UniProtKB; . GO GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB; . GO GO:0016020; C:membrane; IBA:GO_Central; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0047372; F:acylglycerol lipase activity; IDA:UniProtKB; . GO GO:0004622; F:lysophospholipase activity; TAS:ProtInc; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0036155; P:acylglycerol acyl-chain remodeling; TAS:Reactome; . GO GO:0046464; P:acylglycerol catabolic process; IDA:UniProtKB; . GO GO:0019369; P:arachidonic acid metabolic process; ISS:UniProtKB; . GO GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW; . GO GO:0006954; P:inflammatory response; TAS:ProtInc; . GO GO:0006629; P:lipid metabolic process; TAS:ProtInc; . GO GO:2000124; P:regulation of endocannabinoid signaling pathway; ISS:UniProtKB; . GO GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB; . GO GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB; . GO GO:0009966; P:regulation of signal transduction; ISS:UniProtKB; . GO GO:0019433; P:triglyceride catabolic process; IEA:UniProtKB-UniPathway; . Gene3D 3.40.50.1820; -; 1; . InterPro IPR029058; AB_hydrolase; . InterPro IPR000073; AB_hydrolase_1; . InterPro IPR022742; Hydrolase_4; . Pfam PF12146; Hydrolase_4; 1; . PRINTS PR00111; ABHYDROLASE; . SUPFAM SSF53474; SSF53474; 1; . PROSITE PS00120; LIPASE_SER; 1; .

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